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Bing Han
Netherlands
Wageningen Bioveterinary Research
Research Organisation
Host-pathogen interaction, Viral bacterial infection pig model, Co-infection dynamic, Blood micro-sampling
1. Novel Technologies for Prevention, Detection, Assessment and Management of Animal Health and Welfare
The outcome of bacterial infections and the development of disease can vary by the physiological status of the animal and also in the presence of polymicrobial infections. An example of this is the exacerbation of bacterial disease after a priming PRRSV infection. Recent research has shown that not the presence of a certain immune marker at a given moment determines the outcome of an infection, but the kinetic of various immune markers in a period after infection. We have shown that PRRSV type 1 infections can severely increase disease development after S. suis infection compared to a single S. suis infection. The same is true for porcine respiratory infections. The understanding of infection immune dynamic of PRRSV and Streptococcus suis co-infection is limited by sampling frequency due to the animal discomfort and severity of the disease progress. A low-discomfort, low-invasive blood micro-sampling would allow monitoring such infection dynamic via more timely detection during the disease onset. We propose to incorporate existing micro-sampling technology with our PRRSV and Streptococcus suis co-infection pig model, in combination with Luminex, PCR and other possible readouts, thereby providing deeper understanding of the disease, as well as generating a low-invasive monitoring tool for our high tech animal.

Impact of the project
• Better understanding of the disease (host pathogen interaction), therefore allowing development of better countermeasures.
• Generating a new low-invasive tool for infectious disease monitoring (micro-sampling).
• Refinement of a existing animal model (PRRSV and Streptococcus suis co-infection pig model).
• The discovery could be extrapolated to a more timely sample collection method for clinical surveillance in human and animal.
WBVR is a Dutch research institute and part of Wageningen University & Research (WUR). We are the leading veterinary research institute in the Netherlands on animal infectious diseases, including one health and biomedical approaches. Next to strong virological and bacteriological expertise, our facility can perform animal studies under high biosafety levels (up to BSL-3) with strong analytical, sensors and bioinformatics capability.