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Alireza Fazeli
Estonia
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences
University
Computational tool, Extracellular vesicles, RNA, Therapeutics, Microalgae, Livestock farming
2. Prevention and Control
Extracellular vesicles (EVs) are nano-sized particles naturally released by all cell types and are increasingly recognized for their diagnostic and therapeutic potential. Our team at the Institute of Veterinary Medicine and Animal Sciences at Estonian University of Life Sciences consists of experienced researchers with strong expertise in isolation, characterization and application of EVs derived from milk, plants, and various bio fluids. In an innovative and interdisciplinary project, we aim to investigate the therapeutic potential of micro algae-derived EVs as next-generation natural and sustainable therapeutics for livestock infectious diseases.
Project Concept
The project aims to develop natural EV based therapeutics to:
• Control pathogenic bacteria affecting farm animals
• Support and modulate beneficial microbiota
• Provide sustainable alternatives to conventional antibiotics
• Increase the efficiency of currently used antimicrobials
This strategy can address antimicrobial resistance (AMR) and promotes microbiome-friendly disease control in livestock production.
We have capacity to cultivate microalgae at large scale using sustainable production systems. We have strong expertise in the isolation, purification, and characterization of EVs derived from microalgae. To ensure the success of this project, we are seeking complementary expertise in the following areas:
Academic partners:
Bacteriology / Veterinary Microbiology: We are looking for academic collaborators interested in evaluating EV-based natural therapeutics against bacterial infectious diseases in livestock.
Relevant expertise includes: Testing against reference strains (e.g., ATCC collection) and clinically relevant isolates, antimicrobial assays in both planktonic and biofilm states, partners with experience in animal infection models or microbiome-host interaction studies are particularly encouraged.
Bioinformatics: Groups specializing and have experience in RNA–RNA interaction prediction, machine learning approaches, and systems biology would be highly valuable.
Veterinary pharmaceutical or animal health companies interested in:
Testing and validating EV-based formulations, Product development and regulatory pathway exploration, Scale-up and commercialization of sustainable antimicrobial solutions
Project Concept
The project aims to develop natural EV based therapeutics to:
• Control pathogenic bacteria affecting farm animals
• Support and modulate beneficial microbiota
• Provide sustainable alternatives to conventional antibiotics
• Increase the efficiency of currently used antimicrobials
This strategy can address antimicrobial resistance (AMR) and promotes microbiome-friendly disease control in livestock production.
We have capacity to cultivate microalgae at large scale using sustainable production systems. We have strong expertise in the isolation, purification, and characterization of EVs derived from microalgae. To ensure the success of this project, we are seeking complementary expertise in the following areas:
Academic partners:
Bacteriology / Veterinary Microbiology: We are looking for academic collaborators interested in evaluating EV-based natural therapeutics against bacterial infectious diseases in livestock.
Relevant expertise includes: Testing against reference strains (e.g., ATCC collection) and clinically relevant isolates, antimicrobial assays in both planktonic and biofilm states, partners with experience in animal infection models or microbiome-host interaction studies are particularly encouraged.
Bioinformatics: Groups specializing and have experience in RNA–RNA interaction prediction, machine learning approaches, and systems biology would be highly valuable.
Veterinary pharmaceutical or animal health companies interested in:
Testing and validating EV-based formulations, Product development and regulatory pathway exploration, Scale-up and commercialization of sustainable antimicrobial solutions
The Institute of Veterinary Medicine and Animal Sciences at Estonian University of Life Sciences is a public university based in Tartu, Estonia. The institute has a long-standing tradition of excellence in research and development in the fields of Animal welfare, One Health, and Comparative medicine. Through its multidisciplinary approach, it integrates veterinary science, biomedical research, and sustainable livestock production to advance animal health and global health initiatives.