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EUPAHW
Call2
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Jelle Matthijnssens
Belgium
KU Leuven / University of Leuven, Belgium
University
surveillance, pathogen, virus, bacterium, fungi, parasite, metagenomics, probe-based hybridisation, environmental samples, wastewater, indoor air
2. Prevention and Control
We are interested in initiating an EUPAHW project under Objective O3-3, which aims to develop and standardise tools to:
* Differentiate between infected and vaccinated animals (DIVA);
* Determine whether pathogens present in the environment, including waste, remain infectious;
* Study transmission dynamics of pathogens and resistant variants across species, including wildlife.
In particular, we are interested in the objective “to determine whether pathogens in the environment, including waste, remain infectious.” Our team has strong expertise in probe-based hybridisation techniques for detecting a broad range of viral pathogens in wastewater. We propose to combine this expertise with partner laboratories that have the capacity to isolate and culture a variety of viruses, enabling assessment of viral viability and infectivity.
We believe this approach would be valuable to study and detect viruses in animal production systems of a wide range of animals such as pigs, poultry, cattle, horses, etc...
Beyond wastewater, we believe that air samples collected from indoor animal-rearing environments represent a highly valuable and underexplored source for viral surveillance. An important additional objective would be to assess whether viruses detected in these airborne samples remain viable and infectious, thereby contributing to a better understanding of environmental transmission risks.
* Differentiate between infected and vaccinated animals (DIVA);
* Determine whether pathogens present in the environment, including waste, remain infectious;
* Study transmission dynamics of pathogens and resistant variants across species, including wildlife.
In particular, we are interested in the objective “to determine whether pathogens in the environment, including waste, remain infectious.” Our team has strong expertise in probe-based hybridisation techniques for detecting a broad range of viral pathogens in wastewater. We propose to combine this expertise with partner laboratories that have the capacity to isolate and culture a variety of viruses, enabling assessment of viral viability and infectivity.
We believe this approach would be valuable to study and detect viruses in animal production systems of a wide range of animals such as pigs, poultry, cattle, horses, etc...
Beyond wastewater, we believe that air samples collected from indoor animal-rearing environments represent a highly valuable and underexplored source for viral surveillance. An important additional objective would be to assess whether viruses detected in these airborne samples remain viable and infectious, thereby contributing to a better understanding of environmental transmission risks.
KU Leuven (Katholieke Universiteit Leuven) is one of Europe’s leading research universities, founded in 1425 and consistently ranked among the top universities in biomedical and life sciences research. It conducts basic, translational and clinical research across a wide range of disciplines and hosts large interdisciplinary research groups and world-class facilities, with strong links to teaching and health-care delivery.
The Rega Institute for Medical Research is a major biomedical research institute within KU Leuven, focussed on microbiology, immunology, virology, chemotherapy and related areas. It is an interfaculty research centre spanning the Departments of Microbiology & Immunology and Pharmaceutical Sciences and hosts more than 250 scientists working on infectious disease biology, host-pathogen interactions, antiviral and antibiotic discovery, immunobiology, molecular immunology and clinical epidemiology.
Within the Rega Institute, the Laboratory of Viral Metagenomics focuses on the characterisation of viral communities (viromes) from environmental, clinical, and animal-associated samples using next-generation sequencing (NGS). The laboratory develops and applies advanced sample processing workflows, including probe-based hybridisation enrichment approaches combined with NGS, to sensitively detect and characterise a broad range of known and novel viruses. These methods are applied to diverse matrices such as wastewater, air samples, human and animal microbiomes, and vector- and wildlife-associated samples, supporting research into viral diversity, transmission dynamics, zoonotic potential, and population-level virus surveillance.
The Rega Institute for Medical Research is a major biomedical research institute within KU Leuven, focussed on microbiology, immunology, virology, chemotherapy and related areas. It is an interfaculty research centre spanning the Departments of Microbiology & Immunology and Pharmaceutical Sciences and hosts more than 250 scientists working on infectious disease biology, host-pathogen interactions, antiviral and antibiotic discovery, immunobiology, molecular immunology and clinical epidemiology.
Within the Rega Institute, the Laboratory of Viral Metagenomics focuses on the characterisation of viral communities (viromes) from environmental, clinical, and animal-associated samples using next-generation sequencing (NGS). The laboratory develops and applies advanced sample processing workflows, including probe-based hybridisation enrichment approaches combined with NGS, to sensitively detect and characterise a broad range of known and novel viruses. These methods are applied to diverse matrices such as wastewater, air samples, human and animal microbiomes, and vector- and wildlife-associated samples, supporting research into viral diversity, transmission dynamics, zoonotic potential, and population-level virus surveillance.